Synthesis of diversely functionalised 2,2-disubstituted oxetanes: fragment motifs in new chemical space.
نویسندگان
چکیده
Di-, tri- and tetra-substituted oxetane derivatives with combinations of ester, amide, nitrile, aryl, sulfone and phosphonate substituents are prepared as fragments or building blocks for drug discovery. The synthesis of these novel oxetane functional groups, in new chemical space, is achieved via rhodium-catalysed O-H insertion and C-C bond forming cyclisation.
منابع مشابه
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ورودعنوان ژورنال:
- Chemical communications
دوره 51 84 شماره
صفحات -
تاریخ انتشار 2015